Ketamine for treatment resistant depression

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Ketamine for Treatment-Resistant Depression: a New Advocate.

ketamine for treatment resistant depression

Treating Resistant Treatment Depression with Ketamine

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Ketamine was once used mainly as an anesthetic on battlefields and in operating rooms. Now this medication is gaining ground as a promising treatment for some cases of major depression, which is the leading cause of disability worldwide. In the US, recent estimates show 16 million adults had an episode of major depression in the course of a year. Because of its rapid action, ketamine could have a role to play in helping to prevent suicide. If a person responds to ketamine, it can rapidly reduce suicidality life-threatening thoughts and acts and relieve other serious symptoms of depression. Ketamine also can be effective for treating depression combined with anxiety. Other treatments for suicidal thoughts and depression often take weeks or even months to take effect, and some people need to try several medications or approaches to gain relief.

Background: At least % of the patients suffering from depression meet criteria for treatment-resistant depression (TRD). In the last decades, an important .
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Growing evidence shows the potential of ketamine for depression. Research has demonstrated that ketamine provides rapid relief from depressive symptoms and a significant reduction in suicidal ideation , and early this year the FDA approved esketamine nasal spray , combined with an oral antidepressant, for adults with treatment-resistant depression. In late , Columbia University department of psychiatry announced the Columbia Ketamine Program, which offers safe and comprehensive ketamine treatment for eligible adults with treatment-resistant depression at ColumbiaDoctors Midtown in New York City. To learn more about the program, Healio Psychiatry spoke with J. Mann: The program began earlier this year. Intranasal ketamine has been approved by the FDA as an antidepressant for depression that has not responded to at least two other antidepressant medications.

How New Ketamine Drug Helps with Depression

Overcoming therapy resistant depression

Columbia Ketamine Program helps patients with treatment-resistant depression

A study led by Massachusetts General Hospital MGH investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression. In the October issue of Molecular Psychiatry they describe finding that single intravenous doses of 0. Two lower dosage levels that were tested did not provide significant symptom relief, although some improvement was noted with the lowest 0. Long used as a general anesthetic drug, ketamine has been found in several studies to rapidly relieve depression symptoms when given at low, subanesthetic doses. Most of those studies used a standard 0. To investigate that question, the study tested four different ketamine dosages -- 0. Participants were randomized into five groups -- the four dosage levels and the active control group, with neither they nor the research staff aware of group assignments -- and continued taking their previously prescribed antidepressants during the study period.

However, concerns emerged about the optimal dosage, and frequency of administration of this treatment. Twenty-four manuscripts including a total of patients fulfilled inclusion criteria.




5 thoughts on “Ketamine for treatment resistant depression

  1. Ketamine has garnered research attention as a promising agent for treatment- resistant depression (TRD), using a different mechanism of action.

  2. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect.

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