Kynurenine pathway metabolism and the microbiota gut brain axis

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Kynurenine pathway metabolism and the microbiota-gut-brain axis.

kynurenine pathway metabolism and the microbiota gut brain axis

Microbiota–gut–brain–endocrine metabolic interactome - Video abstract 121487

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Skip to search form Skip to main content. Clarkea and Y. Borrea and T. Dinana and J. Cryana Published The brain-gut axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both terminals of this network.

Electronic address: g. It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system CNS function by modulating signalling pathways of the microbiota-gut-brain axis. Understanding the neurobiological mechanisms underpinning the influence exerted by the gut microbiota on brain function and behaviour has become a key research priority. Microbial regulation of tryptophan metabolism has become a focal point in this regard, with dual emphasis on the regulation of serotonin synthesis and the control of kynurenine pathway metabolism. Here, we focus in detail on the latter pathway and begin by outlining the structural and functional dynamics of the gut microbiota and the signalling pathways of the brain-gut axis. We summarise preclinical and clinical investigations demonstrating that the gut microbiota influences CNS physiology, anxiety, depression, social behaviour, cognition and visceral pain.

Interplay of Infection and Microbiome View all 11 Articles. The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan Trp plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immune system by modulating Trp metabolism. Moreover, Trp, endogenous Trp metabolites kynurenines, serotonin, and melatonin , and bacterial Trp metabolites indole, indolic acid, skatole, and tryptamine have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the host-microbiome interface, and host immune system—intestinal microbiota interactions. The aryl hydrocarbon receptor AhR mediates the regulation of intestinal immunity by Trp metabolites as ligands of AhR , which is beneficial for immune homeostasis.

Request PDF on ResearchGate | Kynurenine pathway metabolism and the microbiota-gut-brain axis | It has become increasingly clear that the gut microbiota.
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Tryptophan Trp is an essential amino acid and a precursor of several metabolites involved in key physiological processes. Metabolic pathways leading to serotonin 5-hydroxytryptamine and other metabolites from Trp are under the direct or indirect control of the microbiota. A new review led by Prof. Harry Sokol , a gastroenterologist and researcher from the French National Institute for Agricultural Research INRA and the French Medical Research Institute INSERM , clarifies how the gut microbiota regulates Trp metabolism and identifies the underlying molecular mechanisms of these interactions, based on the pathogenesis of human diseases and potential new treatments. Why did you conduct the review?

In the past few decades, the indoleamine 2,3 dioxygenase IDO subset of the kynurenine KYN pathway of tryptophan TRP metabolism has been the subject of much research in the area of immune tolerance. In this review, we aim to incorporate new findings on this pathway in relation to allergy and the gut microbiome, while providing a comprehensive overview of the pathway itself. Moreover, new evidence from germ-free mice and human infants shows that gut microbiota and breast milk are key in determining the functioning of the KYN-IDO pathway. As such, we recommend further research on how this pathway may be a critical link between the microbiome and development of allergy. The indolamine 2,3-dioxegenase IDO subset of the kynurenine KYN pathway of tryptophan TRP degradation has long been acknowledged to contribute substantially to the control of general inflammation 1.

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tryptophan metabolism towards kynurenine biosynthesis while disrupting the Keywords: microbiota; kynurenine pathway; serotonin; inflammation; gut motility. 1. .. dialogue between the microbiota and gut–brain axis.
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3 thoughts on “Kynurenine pathway metabolism and the microbiota gut brain axis

  1. Targeting the gut microbiota represents a tractable target to modulate kynurenine pathway metabolism. Efforts to develop this approach will markedly increase.

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